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Original Article
- Diabetes, Obesity and Metabolism
- The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes
- Tae Jung Oh, Han Song, Youngil Koh, Sung Hee Choi
- Endocrinol Metab. 2022;37(2):243-248. Published online April 25, 2022
- DOI: https://doi.org/10.3803/EnM.2021.1337
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- 1 Web of Science
- 2 Crossref
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Abstract
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ePub - Background
Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to be associated with increased cardiovascular disease, aging and insulin resistance. Despite the debate of causal contribution of CHIP on metabolic diseases, we want to explore whether CHIP is related to diabetic peripheral neuropathy (DPN).
Methods
This study analyzed the prevalence of CHIP in patients with type 2 diabetes classified according to DPN status. Logistic regression analysis was used to evaluate the association between CHIP and DPN.
Results
CHIP was more prevalent in subjects without DPN than those with DPN (19.9% vs. 8.8%, respectively; P=0.013). Individuals having any CHIP, or DNA methyltransferase 3A (DNMT3A) CHIP were less likely to have any abnormality shown in DPN test; the adjusted odds ratio were 0.85 (95% confidence interval [CI], 0.73 to 1.00) and 0.70 (95% CI, 0.56 to 0.89), respectively. Interestingly, DNMT3A CHIP showed the negative association, but Tet methylcytosine dioxygenase 2 (TET2) CHIP showed the positive association with abnormal feet electrochemical skin conductance level.
Conclusion
On the contrary to expectations, CHIP was negatively associated with DPN. Functional linking between the mutation in hematopoietic cells and DPN, and the opposite role of DNMT3A and TET2 should be investigated. -
Citations
Citations to this article as recorded by
- TET2 mutation as prototypic clonal hematopoiesis lesion
Luca Guarnera, Babal K. Jha
Seminars in Hematology.2024; 61(1): 51. CrossRef - Clonal hematopoiesis with DNMT3A mutation is associated with lower white matter hyperintensity volume
Woo‐Jin Lee, Keun‐Hwa Jung, Han Song, Heesun Lee, Hyo Eun Park, Youngil Koh, Su‐Yeon Choi, Kyung‐Il Park
CNS Neuroscience & Therapeutics.2023; 29(5): 1243. CrossRef
- TET2 mutation as prototypic clonal hematopoiesis lesion
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